Publications 2026
Journal Articles Review Articles Book Chapters Preprints
Journal articles
A modular genetic toolbox for precise gene regulation and multi-color imaging in streptococci
Authors: Mignolet, J., Schmid, A., Staub, J., van der Meer, J.R., Veening, J.W., Libante, V.
Published in: microLife 2026
A microphysiological human mini-bladder reveals urine-urothelium interplay in tissue resilience and UPEC recurrence in urinary tract infections
Authors: Paduthol, G., Nikolaev, M., Sharma, K., Blanc, J., Tomasek, K., Schlunke, L.I.E., Borgeat, V., Ambrosini, G., Kolotuev, I., Clerc-Rosset, S., Gjorevski, N., Knott, G.W., Lütolf, M.P., Thacker, V.V., McKinney, J.D.
Published in: Nature Communications 2026
DOI: 10.1038/s41467-026-68573-3
Preprint: 10.1101/2025.10.28.685030
Urinary tract infections (UTIs) affect hundreds of millions of people each year, and many patients suffer from recurrent infections. In this study, researchers built a bioengineered ‘mini-bladder’ that reproduces key features of the human bladder, including its layered tissue structure and filling-and-emptying cycles. Using this model, they discovered that highly concentrated urine can weaken the bladder’s protective lining, allowing uropathogenic E. coli to persist within the tissue and making infections harder to eliminate. The work reveals a link between urine composition and infection persistence and provides a powerful new platform to study UTIs and test potential therapies under patient-mimicking conditions.
Limited proteolysis-coupled mass spectrometry captures proteome-wide protein structural alterations and biomolecular condensation in living cells
Authors: Elsässer, F., Florea, R., Räsch, F., Zedan, M., Sen, N-E., Pflästerer, T., Kleele, T., Loewith, R., Weis, K., de Souza, N., Picotti, P.
Published in: Molecular Systems Biology 2026
DOI: 10.1038/s44320-025-00182-6
Large-scale testing of antimicrobial lethality at single-cell resolution predicts mycobacterial infection outcomes
Authors: Jovanovic, A., Bright, F.K., Sadeghi, A., Wicki, B., Caño Muñiz, S.E., Giannini, G.C., Toprak, S., Sauteur, L., Rodoni, A., Wüst, A., Lupien, A., Borrell, S., Grogono, D.M., Wheeler, N.E., Dehio, P., Nemeth, J., Pargger, H., Thomson, R., Bell, S.C., Gagneux, S., Bryant, J.M., Peng, T., Diacon, A.H., Floto, R.A., Abanto, M., Boeck, L.
Published in: Nature Microbiology 2026
DOI: 10.1038/s41564-025-02217-y
Review articles
Book chapters
Preprints
Pseudomonas aeruginosa balances cytotoxicity and motility to counter phagocytosis by macrophages
Authors: Distler, T., Tsai, C.-N., Weimann, A., Al-Mayyah, Z., Meirelles, L.A., Floto, R.A., Persat, A.
Preprint: BioRxiv
Publication date: April 3, 2026
DOI: 10.64898/2026.04.02.716043
Lysosomal activation in bladder epithelium enhances intracellular antibiotic clearance of uropathogenic Escherichia coli
Authors: Tomasek, K., Skurvydaite, K., Paduthol, G., Burns, A.M., Schlunke, L., Borgeat, V., Pasquali, C., Romani, M., McKinney, J.D.
Preprint: BioRxiv
Publication date: March 24, 2026
DOI: 10.1101/2025.10.22.683857
Evolved resistance against the type 6 secretion system is toxin specific
Authors: Smith, W., Tejada Arranz, A., Tank, R., Basler, M., Brockhurst, M.
Preprint: BioRxiv
Publication date: March 17, 2026
DOI: 10.64898/2026.03.17.712380v1?ct=
Influence of microbial composition and sample type on antimicrobial resistance in urinary tract infections: a single-centre retrospective cohort study (2015–2023)
Authors: Dubey, A.K., Reyes, J., Rhiner, C., Drescher, K., Dunkel, J., McKinney, J., Egli, A.
Preprint: medRxiv
Publication date: March 02, 2026
DOI: 10.64898/2026.02.23.26344629
A functional genetic landscape of antibiotic sensitivity across the pneumococcal pangenome reveals conserved and lineage-specific vulnerabilities
Authors: Sewgoolam, B., Janssen, A.B., Martin, L.S., Rengifo-Gonzalez, M., de Bakker, V., Rozendal, B., Cremers, A.J.H., Veening, J.W.
Preprint: BioRxiv
Publication date: February 26, 2026
DOI: 10.64898/2026.02.26.708248v1?ct=
Mechanistic basis of teichoic acid transport by a gatekeeper flippase
Authors: Cebrero, G., Chidananda, A.H., Cester, E., Denereaz, J., Demir, E.S., Mathew, A.T., Bhowmik, D.R., de Capitani, M., Reymond, J.-L., Kannan, N., Avci, F., Mehdipour, A.R., Veening, J.-W., Perez, C.
Preprint: BioRxiv
Publication date: February 23, 2026
DOI: 10.64898/2026.02.22.707263v1?ct=
Opposing Range-Dependent Interactions Create Complex Spatial Patterns of Antibiotic Tolerance in Multispecies Biofilms
Authors: Bottacin, G., Raach, B., Fröhlich, L., Künnecke, J., Kaczmarczyk, A., Tejada-Arranz, A., Ugolini, G.S., Stocker, R., Jenal, U., Bumann, D., Dittrich, P.S., Schubert, O.T., van Vliet, S.
Preprint: BioRxiv
Publication date: February 6, 2026
DOI: 10.64898/2026.02.04.703747
Monitoring intracellular antibiotic concentrations in real-time using allosteric biosensors
Authors: Fleckenstein, D., Kaczmarczyk, A., Breitenbach-Netter, N., Rosenberg, G., Jakob, R.P., Sorg, I., Kurmashev, A., Flores, C., Jiménez-Siebert, E., Morris, E., Klimke, S., Tschudin-Sutter, S., Hierlemann, A., Maier, T., Dehio, C., Jenal, U., Drescher, K.
Preprint: BioRxiv
Publication date: February 5, 2026
DOI: 10.64898/2026.02.05.704027
