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NCCR AntiResist

New approaches to combat antibiotic-resistant bacteria

NCCR AntiResist

NCCR AntiResist

New approaches to combat antibiotic-resistant bacteria

NCCR AntiResist

NCCR AntiResist

New approaches to combat antibiotic-resistant bacteria

NCCR AntiResist

NCCR AntiResist

New approaches to combat antibiotic-resistant bacteria

Revitalizing antibiotic discovery by a patient-centered paradigm shift

Antibiotics are powerful and indispensable drugs to treat life threatening bacterial infections, such as sepsis or pneumonia. Antibiotics also play a central role in many other areas of modern medicine, in particular to protect patients with a weakened immune system during cancer therapies, transplantations or surgical interventions. These achievements are now at risk, with the fraction of bacterial pathogens that are resistant to one or more antibiotics steadily increasing.

The discovery and development of novel antibiotics faces complex societal, economic, technological and scientific challenges. The declining pipeline for novel antibiotics and increasing resistance to existing drugs gradually reduces the options clinicians have to treat bacterial infections.

NCCR AntiResist

The National Center of Competence in Research AntiResist aims to bring about a paradigm shift in antibiotic research with an interdisciplinary approach that assembles a Swiss-wide network of research groups from the fields of clinical research, biology, chemistry, computation, engineering and pharmacology.

The research program is structured into three four-year phases covering strategically and dynamically evolving milestones. Research activities center around a better understanding of pathogen physiology in patients; developing axenic and tissue-based model systems mimicking patient environments; and engineering of novel screening platforms for the next generation of antibiotics.

NCCR AntiResist is funded by the Swiss National Science Foundation, and the home institution is the University of Basel.

Watch below our short video produced by the University of Basel.

News and Events

Nature Medicine paper from the Borgwardt & Egli Labs

Using Machine Learning for Faster AMR Prediction

Collaborative research between the ETH-Zürich D-BSSE, the University Hospital of Basel, and the University of Basel uses machine learning to speed up Antimicrobial Resistance detection. Research groups, including NCCR AntiResist Principle Investigators Karsten Borgwardt and Adrian Egli developed a new method using mass spectrometry data to detect antibiotic resistant bacteria more quickly than traditional lab diagnostics. This can help doctors prescribe the proper antibiotics to patients, which in turn helps stop the spread of antimicrobial resistance. 

Original publication:

Weis, C., Cuénod, A., Rieck, B. et al. Direct antimicrobial resistance prediction from clinical MALDI-TOF mass spectra using machine learning. Nat Med (2022). https://doi.org/10.1038/s41591-021-01619-9

Read the German press release from the University of Basel here.

Read the English press release from ETH Zurich D-BSSE here.

PhD Fellowship Call

We are thrilled to announce the opening of our NCCR AntiResist Fellowship Call – apply now

Application deadline is March 1, 2022.

For more information, visit our "Education & Training" page. 

Talks in December

Monday, 06.12.2021, 5:15 PM,  NCCR AntiResist Special Seminar as part of a University of Basel internal lecture series, Prof. Roi Avraham, Weizmann Institute of Science, Israel. "Dynamic states of immune-bacteria encounters at early stages underlie infection outcome." This is an on-line event. Please contact Sarah Thomforde for more information.

Thursday, 09.12.2021, 12:30 PM, Basel Infectious Diseases Study Club, Prof. Maja Weisser Rohacek, University Hospital Basel, will speak on “COVID-19 and the use of convalescent plasma”; Dr. Minia Antelo Varela, Biozentrum of the University of Basel, will speak on “Proteome analysis of Staphylococcus aureus in deep-seated human infections”. Zoom invitation for NCCR AntiResist affliated members. Please contact Sarah Thomforde for more information.

World Antimicrobial Awareness Week

Every year November 18 - 24th is dedicated to Antimicrobial Resistance awareness.  This year the topic is "Spread Awareness, Stop Resistance". You can find useful information, see what international events are planned and watch a video from WHO Director General, Dr. Tedros Adhanom Ghebreyesus here. 

#NCCRWomen Video Series

To celebrate Women's Day 2021 and the 50th Anniversary of women's right to vote in Switzerland, we are working with our sister NCCRs across the country to release a series of videos showcasing women working in science. The week of October 11-15 highlights female scientists at NCCR AntiResist: Nina Khanna, Vishwachi Tripathi, Ikram Salah, Valentina Cappelletti and Julia Boos.  You can watch the videos on YouTube or Instagram. Watch, share and be inspired! 

INCATE Launch

NCCR AntiResist is exited to announce the launch of INCATE: Incubator for Antibacterial Therapies Europe. INCATE (INCubator for Antibacterial Therapies in Europe) is launching on August 25th to support innovators in the fight against drug-resistant bacterial infections. INCATE is a partnership between academic members, industry, and other supporting partners. It will help to bridge the gap between research and industry for treatments, diagnostics and interventions that reduce the prevalence and impact of Antimicrobial Resistance (AMR).

Read more at their webpage here.