2021

Mutasynthetic Production and Antimicrobial Characterization of Darobactin Analogs

Authors: Böhringer, N.*, Green, R.*, Liu, Y., Mettal, U., Marner, M., Modaresi, S.M., Jakob, R.P., Wuisan, Z.G., Maier, T., Iinishi, A., Hiller, S., Lewis, K.*, and Schäberle, T.F.*

Published in: Microbiology Spectrum 2021 Vol. 9 Issue 3

DOI: 10.1128/SPECTRUM.01535-21

Systematic exploration of Escherichia coli phage-host interactions with the BASEL phage collection

Authors: Maffei, E.*, Shaidullina, A.*, Burkolter, M., Heyer, Y., Estermann, F., Druelle, V., Sauer, P., Willi, L., Michaelis, S., Hilbi, H., Thaler, D. S., and Harms, A.

Published in: PLoS Biology 2021 Vol. 19 Issue 11

DOI: 10.1371/journal.pbio.3001424

Spatial alanine metabolism determines local growth dynamics of Escherichia coli colonies

Authors: Díaz-Pascual, F., Lempp, M., Nosho, K., Jeckel, H., Jo, J.K., Neuhaus, K., Hartmann, R., Jelli, E., Hansen, M.F., Price-Whelan, A., Dietrich, L.E. P., Link, H., and Drescher, K.

Published in: Elife 2021 Vol. 10

DOI: 10.7554/eLife.70794

Antibiotic Tolerance and Persistence Studied Throughout Bacterial Growth Phases

Book Chapter 

Authors: Maffei, E., Fino, C., and Harms, A.

Published in: Methods in Molecular Biology 2021 Vol. 2357

DOI: 10.1007/978-1-0716-1621-5_2

Outer membrane permeability: Antimicrobials and diverse nutrients bypass porins in Pseudomonas aeruginosa

Authors: Ude, J.*, Tripathi, V.*, Buyck, J.M., Soderholm, S., Cunrath, O., Fanous, J., Claudi, B., Egli, A., Schleberger, C., Hiller, S., and Bumann, D.

Published in: PNAS 2021 Vol. 118 Issue 31

DOI: 10.1073/pnas.2107644118

 

Early invasion of the bladder wall by solitary bacteria protects UPEC from antibiotics and neutrophil swarms in an organoid model

Authors: Sharma, K., Thacker, V.V., Dhar, N., Clapes Cabrer, M., Dubois, A., Signorino-Gelo, F., Mullenders, J., Knott, G.W., Clevers, H., and McKinney, J.D.

Published in: Cell Reports 2021 Vol. 36 Issue 3

DOI: 10.1016/j.celrep.2021.109351

Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

Authors: Sharma, K., Dhar, N., Thacker, V.V., Simonet, T.M., Signorino-Gelo, F., Knott, G.W., and McKinney, J.D.

Published in: Elife 2021 Vol. 10

DOI: 10.7554/eLife.66481

Pareto optimality between growth-rate and lag-time couples metabolic noise to phenotypic heterogeneity in Escherichia coli

Authors: Fuentes, D.A.F., Manfredi, P., Jenal, U., and Zampieri, M. 

Published in: Nature Communications 2021 Vol. 12 Issue 1

DOI: 10.1038/s41467-021-23522-0

The antibiotic darobactin mimics a beta-strand to inhibit outer membrane insertase

Authors: Kaur, H.*, Jakob, R. P.*, Marzinek, J. K., Green, R., Imai, Y., Bolla, J. R., Agustoni, E., Robinson, C. V., Bond, P. J., Lewis, K.*, Maier, T.*, and Hiller, S*. 

Published: Nature 2021 Vol. 593 Issue 7857

DOI: 10.1038/s41586-021-03455-w

Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections

Authors: Santi, I., Manfredi, P., Maffei, E., Egli, A., and Jenal, U.

Published in: mBio 2021 Vol. 12 Issue 1

DOI: 10.1128/mBio.03482-20

Exploration of Bacterial Bottlenecks and Streptococcus pneumoniae Pathogenesis by CRISPRi-Seq

Authors: Liu, X., Kimmey, J.M., Matarazzo, L., de Bakker, V., Van Maele, L., Sirard, J.C., Nizet, V., and Veening, J.W.

Published in: Cell Host Microbe 2021 Vol. 29 Issue 1

DOI: 10.1016/j.chom.2020.10.001