2022

Antibiotic polymyxin arranges lipopolysaccharide into crystalline structures to solidify the bacterial membrane

Authors: Manioglu, S., Modaresi, S.M., Ritzmann, N., Thoma, J., Overall, S.A., Harms, A., Upert, G., Luther, A., Barnes, A.B., Obrecht, D., Müller, D.J.*, and Hiller, S.*

Published in: Nature Communications 2022 

DOI: 10.1038/s41467-022-33838-0

Limited Proteolysis–Mass Spectrometry to Identify Metabolite–Protein Interactions.

Book Chapter 

Authors: Holfeld, A., Quast, J.P., Bruderer, R., Reiter, L., de Souza, N., and Picotti, P.

Published in: Methods in Molecular Biology 2023 Vol. 2554

DOI: 10.1007/978-1-0716-2624-5_6

reComBat: batch-effect removal in large-scale multi-source gene-expression data integration

Authors: Adamer, M.F.*, Brüningk, S.C.*, Tejada-Arranz, A., Estermann, F., Basler, M., and Borgward, K.

Preprint: Bioinformatics Advances

DOI: 10.1093/bioadv/vbac071

Computational identification of a systemic antibiotic for gram-negative bacteria

Authors: Miller, R.D.*, Iinishi, A.*, Modaresi, S.M.*, Yoo, B.K.*, Curtis, T.D., Lariviere, P.J., Liang, L., Son, S., Nicolau, S., Bargabos, R., Morrissette, M., Gates, M.F., Pitt, N., Jakob, R.P., Rath, P., Maier, T., Mayutin, A.G., Kaiser, J.T., Niles, S., Karavas, B., Ghiglieri, M., Bowman, S., Rees, D.C., Hiller, S.*, and Lewis, K.*

Published in: Nature Microbiology 2022 

DOI: 10.1038/s41564-022-01227-4

INCATE: a partnership to boost the antibiotic pipeline

Comment

Authors: Alt, S., Haggstrom, D., Kessmann, H., Kloss, F., Schneider, C.E., Jäger, T., Schwede, T., Brakhage, A., and Dehio, C.

Published in: Nature Reviews Drug Discovery 2022 

DOI: https://www.nature.com/articles/d41573-022-00138-7​​​​​​​

Antibiotic persistence of intracellular Brucella abortus

Authors: Mode, S.*, Ketterer, M.*, Québatte, M.*, and Dehio, C.

Published in: PLoS Negl Trop Dis. 2022 

DOI: 10.1371/journal.pntd.0010635

The acquisition of clinically relevant amoxicillin resistance in Streptococcus pneumoniae requires ordered horizontal gene transfer of four loci

Authors: Gibson, P.S., Bexkens, E., Zuber, S., Cowley, L.A. , and Veening, J.W.

Published in: PLoS Pathogens 2022 

DOI: 10.1371/journal.ppat.1010727

Circuit-Based Design of Microfluidic Drop Networks

Authors: Rousset, N., Lohasz, C., Boos, J.A., Misun, P.M., Cardes, F., and Hierlemann, A.

Published in: Micromachines 2022 Vol. 13 Issue 7

DOI: 10.3390/mi13071124

Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

Authors: Dewachter, L., Dénéréaz, J., Liu, X., de Bakker, V., Costa, C., Baldry, M., Sirard, J.C., and Veening, J.W.

Published in: eLife 2022 

DOI: 10.7554/eLife.75607

Mechanisms Underlying Vibrio cholerae Biofilm Formation and Dispersion

Review article 

Authors: Teschler, J.K., Nadell, C.D., Drescher, K., and Yildiz, F.H.

Published in: Annual Review of Microbiology 2022 Vol. 76

DOI: 10.1146/annurev-micro-111021-053553

Pseudomonas aeruginosa contracts mucus to rapidly form biofilms in tissue-engineered human airways

Authors: Rossy, T., Distler, T., Pezoldt, J., Kim, J., Talà, J., Bouklas, N., Deplancke, B., and Persat, A.

Preprint: BioRxiv

DOI: 10.1101/2022.05.26.493615

Expanding the search for small-molecule antibacterials by multidimensional profiling

Review article 

Authors: Ortmayr, K., de la Cruz Moreno, R., and Zampieri, M.

Published in: Nature Chemical Biology 2022 Vol. 18 Issue 6

DOI: 10.1038/s41589-022-01040-4

High-throughput screening of BAM inhibitors in native membrane environment

Authors: Rath, P., Hermann, A., Schaefer, R., Agustoni, E., Vonach, JM., Siegrist, M., Miscenic, C., Tschumi, A., Roth, D., Bieniossek, C., and Hiller, S.

Preprint: Research Square

DOI: 10.21203/rs.3.rs-1465417/v1

Combining CRISPRi and metabolomics for functional annotation of compound libraries

Authors: Anglada-Girotto, M., Handschin, G., Ortmayr, K., Campos, A.I., Gillet, L., Manfredi, P., Mulholland, C.V., Berney, M., Jenal, U., Picotti, P., and Zampieri, M.

Published in: Nature Chemical Biology 2022 Vol. 18 Issue 5

DOI: 10.1038/s41589-022-00970-3

Phage Paride hijacks bacterial stress responses to kill dormant, antibiotic-tolerant cells

Authors: Maffei, E., Burkolter, M., Heyer, Y., Egli, A., Jenal, U., and Harms, A.

Preprint: BioRxiv

DOI: 10.1101/2022.01.26.477855

CRISPRi-seq for genome-wide fitness quantification in bacteria

Authors: de Bakker, V.*, Liu, X.*, Bravo, A.M., and Veening, J.W.

Published in: Nature Protocols 2022 Vol. 17 Issue 2

DOI: 10.1038/s41596-021-00639-6

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